General Information

  • ID:  hor004942
  • Uniprot ID:  P14596
  • Protein name:  Hypertrehalosaemic factor
  • Gene name:  NA
  • Organism:  Tabanus atratus (Black horse fly)
  • Family:  AKH/HRTH/RPCH family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Tabanus (genus), Tabanini (tribe), Tabaninae (subfamily), Tabanidae (family), Tabanoidea (superfamily), Tabanomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QLTFTPGWGY
  • Length:  10(1-10)
  • Propeptide:  QLTFTPGWGY
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T10 Tyrosine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Elevate the level of trehalose in the hemolymph
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004942_AF2.pdbhor004942_ESM.pdb

Physical Information

Mass: 133001 Formula: C57H76N12O15
Absent amino acids: ACDEHIKMNRSV Common amino acids: GT
pI: 6.09 Basic residues: 0
Polar residues: 5 Hydrophobic residues: 3
Hydrophobicity: -29 Boman Index: 129
Half-Life / Aliphatic Index: 0.8 hour Aliphatic Index: 39
Instability Index: 1482 Extinction Coefficient cystines: 6990
Absorbance 280nm: 776.67

Literature

  • PubMed ID:  2813385
  • Title:  Primary structure of two neuropeptide hormones with adipokinetic and hypotrehalosemic activity isolated from the corpora cardiaca of horse flies (Diptera).